PI Nano series nanopositioning stages by Physik Instrument, Auburn, MA, feature a profile of just 20 mm and deliver accurate motion with sub-nanometer resolution in 2 and 3 axes.  A piezo controller is included and comes with a 24-bit USB port, Ethernet, RS-232 and an analog interface, as well as solid software support for all major image acquisition packages. The piezo stage is supplemented by the optional M-545 manual XY microscope stage available in different versions for Olympus, Nikon, Zeiss and Leica microscopes. The PI Nano series of piezo stages extends PI's P-527, P-733 and P-563 series of capacitive direct-metrology nanopositioning stages. PI Nano series systems were developed to provide high performance at lower cost by adapting mechanics and controller exactly to the requirements of the target applications. For highly stable, closed-loop operation, piezoresistive sensors are applied directly to the moving structure and precisely measure the displacement of the stage platform. The high sensitivity of the sensors provides position stability and responsiveness as well as sub-nanometer resolution. Applications include scanning microscopy, single molecule microscopy, 3D imaging, auto-focusing, scanning, and alignment tasks in bio-nanotechnology.