TissueMark aids in locating the tumor boundary and with the additional benefit of a heat map, it can also show the areas of higher concentrated tumor. (Image courtesy of PathXL.)
In terms of manual tissue sample slide marking, the naked eye is good at recognizing broad patterns and assessing context, but often lacks the ability to precisely measure slight deviations in colors and patterns. TissueMark is a new analysis software program developed to bridge the diagnostic inconsistency gaps for cancer characteristics in tissue between pathologists reviewing the same case. TissueMark aims to streamline macrodissection for molecular analysis and biomarker discovery through image analysis as well as save time and provide more consistent tumor calculations.
Developed by PathXL, TissueMark works with all major slide-scanning platforms to look more closely into the structure of tissue samples. A tissue heat map is then rendered, providing more actionable information than possible by manual inspection. The software can simultaneously inspect hundreds of image features and is tailored specifically for the detection of several forms of cancer by detecting minute changes in color information and pixel organization associated with cancer cells. Pathologists can then operate remotely, view the images and annotations at any resolution, and securely archive the data for later review.
TissueMark was developed over an 18-month period in conjunction with pathologists of Queen’s University in Canada. Researchers at PathXL compared markups from the pathologists with the results from the software. The pathologists were asked to mark the same tissue samples more than once, with different results shown each time. The TissueMark software has the potential to lead to a more consistent, accurate analysis and at a faster speed—capable of marking as many tissue samples in 10 minutes than an experienced pathologist can mark in a day—than the human specialists.
Watch the video from PathXL below for more information on the TissueMark software.