Epilepsy is Newsweek’s April 20 cover story. The 13-page feature includes information on intracranial electrical stimulation systems now in late-stage clinical trials.  Harvard neurologist American Epilepsy Society President Steven Schacter is quoted in the article as saying researchers are working to develop responsive devices that could be implanted in the brain and “sense when a seizure is beginning, to release a small amount of medication or electrical stimulation when needed.  The article goes on to say that the key to such devices is the computer algorithms for predicting seizures. Algorithmic EEG analysis would detect seizure onset prior to symptoms or clinical signs. These systems, and others that detect non-electrical markers of impending seizures, would enhance patient safety and the effectiveness of abortive therapies either administered by patients/caregivers or automatically via closed-loop systems. This continues to be a complex task as the brain’s 100 billion neurons are linked to as many as 10,000 others throughout the body. Or as Newsweek puts it, “to conquer epilepsy, we will have to outwit our own brains.”